Azole antifungal agents: emphasis on new triazoles
نویسندگان
چکیده
منابع مشابه
Antifungal agents: Polyene, azole, antimetabolite, other and future agents
Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality. This study is desig...
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The first synthesis of both enantiomers of the antifungal drug bifonazole (1a) and related imidazole compounds 1i and 5b,c is described, starting from enantiomerically pure or enriched amines 6a–d. Construction of the imidazole ring on amines 6a–d was performed in a straightforward manner affording the final compounds in good overall yield and with very high enantiomeric purity, as determined b...
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Over the past 10-15 years, the number of clinically available antifungal agents has increased substantially, due to rise in the number of invasive fungal infections, which are a real problem for specialists. Echinocandins are the new class of antifungal agents available for clinical use. This class comprises over 20 natural echinocandins and several semisynthetic ones. Natural echinocandins are...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1988
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.32.1.1